Peroxisomes
Peroxisomal stress responses
Peroxisomes are essential metabolic organelles, yet how cells sense and respond to peroxisomal dysfunction remains poorly understood. We study the quality-control and transcriptional pathways activated by peroxisomal stress using temperature-sensitive C. elegans models of peroxisome biogenesis disorders and tissue-specific degron-based perturbations that allow spatial and temporal control of peroxisome function. We complement these in vivo approaches with mammalian cell culture and patient-derived cells to define conserved peroxisome stress responses and mechanisms of recovery.
